milk thistle depression

Did you know that milk thistle has recently been touted as a natural remedy to help manage the debilitating symptoms of OCD? 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Elsevier; 2021. https://www.clinicalkey.com. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. JIN_FK8R Please rate my stack I know I'm Fxxked up for now. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. National Library of Medicine Pain in . Review/update the But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. A 2010 review by researchers found that black . Healthline Media does not provide medical advice, diagnosis, or treatment. Do not use extra milk thistle to make up the missed dose. Eighteen clinical trials of 1,088 participants were assessed. Reflux Risk and Relief View More . While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). Milk thistle can also be taken with cholesterol-lowering medications, like statins. Milk thistle. Copyright 1996-2023 Cerner Multum, Inc. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. [Database subscription]. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. However, human studies are limited and havent yet shown any beneficial effects. Do not give any herbal/health supplement to a child without medical advice. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Pizzorono JE, et al., eds. Exercise caution and start slow. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. MeSH If youre pregnant or breastfeeding, check with your doctor before using milk thistle. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. Read our. Advertising revenue supports our not-for-profit mission. Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. Before Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Our website services, content, and products are for informational purposes only. Recent research has explored the use of milk thistle. However, this is the only clinical study available. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Bookmark the permalink. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3). Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Careers. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. All rights reserved. Occasionally, people report various digestive side effects. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). Also known as Silybum marianum, milk thistle is a perennial herb native to many continents and countries across the globe, including Southern Europe, Southern Russia, Asia Minor, Northern Africa, and the Americas. Epub 2019 Nov 24. However, many of these potential benefits are not backed by science. 2016;5147468. doi:10.1155/2016/5147468. These side effects may be mild or severe. Osteoporosis is a disease caused by progressive bone loss. This content does not have an Arabic version. Medically reviewed by Drugs.com on Sep 29, 2022. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. Phytother Res. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. Clipboard, Search History, and several other advanced features are temporarily unavailable. Historically, people have used milk thistle for liver disorders and gallbladder problems. These include: Summary Milk thistle is generally considered safe. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Benefits. Risks. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Int J Mol Sci. information submitted for this request. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. People may also find it painful and worry about its effects on their appearance. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. National Center for Complementary and Integrative Health. Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. Longe, J., ed. Tadaah, perhaps a partly explanation for your experience? Milk thistle is a plant named for the white veins on its large prickly leaves. Just amazing and timely information at your fingertips. An official website of the United States government. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. Phytother Res. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Epub 2023 Mar 4. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. However, the evidence is conflicting. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Other studies looking at milk thistle for cirrhosis have found conflicting results. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). It is primarily considered a cleansing agent and used to block or flush toxins from the body. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. Epub 2016 Dec 22. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). To ensure quality and potency in your herbal remedies, why not grow your own? Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. JAMA. This content does not have an English version. Beware that milk thistle can worsen depression, it doesn't act the same on everybody. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Questions? One study questioned the benefits of milk thistle for liver diseases. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Milk thistle. Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). Depression and anxiety are associated with increased risk of developing AD. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Researchers also have found that milk thistle improved insulin resistance, a key part of type 2 diabetes. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. While milk thistle is considered a noxious weed in various parts of the United States, it has little oral consumption value and is best absorbed in tablet or capsule supplement form, but can also be consumed as a tea or oral tincture. Biomed Res Int. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. 2023 Natural Wellness. People have traditionally used milk thistle for problems with the liver and gallbladder . Effects of Silybum marianum (L.) Gaertn. It is native to Mediterranean countries. other information we have about you. Some people may be allergic to milk thistle. Can You Get Milk Thistle Naturally From Foods? One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Milk thistle. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). What Is Complementary, Alternative, or Integrative Health? By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Using different formulations together increases the risk of an overdose. But the herb is also believed to be beneficial for other health issues. Do not use this product without medical advice if you are breast-feeding a baby. Therefore, it may be best to avoid milk thistle during these life stages. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. Natural Medicines website. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. . Adv Ther. FREE standard shipping only available in the contiguous United States. 2014;2014:941085. doi:10.1155/2014/941085. Milk thistle can trigger allergic reactions. Malaria. WebMD does not provide medical advice, diagnosis or treatment. Available for Android and iOS devices. Milk thistle has been an important natural remedy for centuries of folk medicine practitioners. By Brittany Lubeck, RD Skip the missed dose if it is almost time for your next scheduled dose. Camini FC, Costa DC. 2020;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. Please enable it to take advantage of the complete set of features! A double-blind controlled study. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". But experts say that the evidence isnt conclusive. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. People with diabetes should use caution. Some, but not all, milk thistle supplements are vegan. If we combine this information with your protected Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Nevertheless, pregnant women, those allergic to the Asteraceae family of plants, those with diabetes and anyone with an estrogen-sensitive condition should seek medical advice before taking it. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. J Diabetes Res. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. include protected health information. It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. Together, you can make shared, well-informed decisions. https://www.wolterskluwercdi.com/facts-comparisons-online/. These products are not intended to diagnose, treat, cure, or prevent any disease. Trigonella foenum-graecum(fenugreek)also is used for this reason. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). However, there are currently no human studies, so its effectiveness remains unclear. sharing sensitive information, make sure youre on a federal Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. To provide you with the most relevant and helpful information, and understand which Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. You may report side effects to FDA at 1-800-FDA-1088. However, as this is the only study, more high-quality research is needed. One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Drug class: Herbal products. Milk thistle may also be used for purposes not listed in this product guide. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. J Diabetes Res. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. This article will explore the uses of milk thistle and research on its potential benefits. People sometimes eat the stem and leaves of milk thistle in salads. Eur Endocrinol. There are other supplements that work similarly to milk thistle. Side effects are always possible when taking supplements. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Milk thistle is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita phalloides (death cap) mushroom poisoning, jaundice, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Combining silybin with phosphatidylcholine and other phospholipids enhances the absorption of milk thistle's active compounds, providing powerful liver health support. Multiple Myeloma vs. Leukemia: What Are the Differences? Silymarin: not just another antioxidant. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Our study provides a new insight into the protective effects of silibinin in the treatment of anxiety/depression. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. There are no other food sources of this herb. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. The mention of any product, service, or therapy is not an endorsement by NCCIH. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Epub 2016 Mar 9. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. It also states that Milk Thistle will lower Ferritin and that iron-supplement is advised. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. However, there is no solid evidence that supports these claims. One human trial found it to work as well as fluoxetine to manage OCD symptoms. And Selenium too. It could interact with many drugs, including some that treat high cholesterol, infections, insomnia, and blood pressure. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. information is beneficial, we may combine your email and website usage information with Silymarin as supportive treatment in liver diseases: a narrative review. Accessed Oct. 30, 2020. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. Learn more about natural remedies for type 2 diabetes. Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. The benefits of milk thistle can be attributed to its anti-inflammatory and antioxidant effects. Scan J Gastroenterol. Brain Fog (anxiety, depression, ADHD), lots of medications. It is not known whether milk thistle will harm an unborn baby. Unexpected effects from milk thistle. PMC Some of the studies have been of poor quality, too. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Silybum marianum (milk thistle). Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Learn. Taken in appropriate doses, oral use of milk thistle appears to be safe. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. FOIA Milk thistle is promoted as a dietary supplement for . Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. No supplement is intended to treat, cure, or prevent disease. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Not available for orders containing UltraNourish. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Before taking milk thistle, talk to your doctor, pharmacist, or health care professional if you have allergies (especially to plants), have any medical conditions, or if you take other medicines or other herbal/health supplements. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. This site needs JavaScript to work properly. Here are 10 of the best herbs for your liver, including benefits and. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. Milk thistle is native to Europe and was introduced into North America by early colonists. Milk thistle. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. eCollection 2023. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. In: Textbook of Natural Medicine. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. In fact, it has traditionally been used to treat liver and gallbladder disorders, promote breast milk production, prevent and treat cancer and even protect the liver from snake bites, alcohol and other environmental poisons. Pharmacol Rev. Can Milk Thistle Help People With Diabetes? They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). 2012;308(3):274-282. doi:10.1001/jama.2012.8265, Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. 5th ed. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Seeff, L.; Curto, T.; Szabo, G. et al. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Interactions. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy.

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milk thistle depression